Groitl Bastian, Jakob Ursula
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Biochim Biophys Acta. 2014 Aug;1844(8):1335-43. doi: 10.1016/j.bbapap.2014.03.007. Epub 2014 Mar 19.
Regulation of protein function through thiol-based redox switches plays an important role in the response and adaptation to local and global changes in the cellular levels of reactive oxygen species (ROS). Redox regulation is used by first responder proteins, such as ROS-specific transcriptional regulators, chaperones or metabolic enzymes to protect cells against mounting levels of oxidants, repair the damage and restore redox homeostasis. Redox regulation of phosphatases and kinases is used to control the activity of select eukaryotic signaling pathways, making reactive oxygen species important second messengers that regulate growth, development and differentiation. In this review we will compare different types of reversible protein thiol modifications, elaborate on their structural and functional consequences and discuss their role in oxidative stress response and ROS adaptation. This article is part of a Special Issue entitled: Thiol-Based Redox Processes.
通过基于硫醇的氧化还原开关对蛋白质功能进行调控，在细胞对活性氧（ROS）水平的局部和整体变化的响应及适应过程中发挥着重要作用。氧化还原调节被诸如ROS特异性转录调节因子、伴侣蛋白或代谢酶等第一响应蛋白所利用，以保护细胞免受不断增加的氧化剂水平的影响，修复损伤并恢复氧化还原稳态。磷酸酶和激酶的氧化还原调节用于控制特定真核信号通路的活性，使活性氧成为调节生长、发育和分化的重要第二信使。在本综述中，我们将比较不同类型的可逆蛋白质硫醇修饰，阐述其结构和功能后果，并讨论它们在氧化应激反应和ROS适应中的作用。本文是名为：基于硫醇的氧化还原过程的特刊的一部分。
