GABA 能信号通过促进 ERK1/2 依赖性磷酸化促进乳腺癌转移。
GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation.
机构信息
Department of Physiology, School of Medicine, Shandong University, Jinan 250012, China.
Department of Physiology, School of Medicine, Shandong University, Jinan 250012, China.
出版信息
Cancer Lett. 2014 Jun 28;348(1-2):100-8. doi: 10.1016/j.canlet.2014.03.006. Epub 2014 Mar 18.
The present study aims to determine the role of γ-aminobutyric acid (GABA) signaling molecules in breast cancer metastasis. Our results reveal that GABAergic system exists in breast cancer cells. Both the GABA synthetic enzyme. (GAD65/67) and GABAB receptor are expressed in 4T1 mouse breast cancer cells, MCF-7 human breast cancer cells and human breast cancer tissue. Baclofen, a GABABR agonist, significantly promoted 4T1 cells invasion and migration in vitro and metastasis in vivo, an event that was attenuated by GABABR antagonist CGP55845. Baclofen-induced breast cancer metastasis was mediated by ERK1/2 pathway.
本研究旨在确定γ-氨基丁酸（GABA）信号分子在乳腺癌转移中的作用。我们的结果表明 GABA 能系统存在于乳腺癌细胞中。GABA 合成酶（GAD65/67）和 GABAB 受体均在 4T1 小鼠乳腺癌细胞、MCF-7 人乳腺癌细胞和人乳腺癌组织中表达。Baclofen，一种 GABABR 激动剂，显著促进了体外 4T1 细胞的侵袭和迁移以及体内转移，而 GABABR 拮抗剂 CGP55845 则减弱了这种作用。Baclofen 诱导的乳腺癌转移是通过 ERK1/2 途径介导的。
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