将重组蜘蛛丝蛋白加工成用于生物材料应用的定制材料。
Processing of recombinant spider silk proteins into tailor-made materials for biomaterials applications.
作者信息
Schacht Kristin, Scheibel Thomas
机构信息
Lehrstuhl Biomaterialien, Fakultät für Ingenieurwissenschaften, Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany.
Lehrstuhl Biomaterialien, Fakultät für Ingenieurwissenschaften, Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany; Bayreuther Zentrum für Kolloide und Grenzflächen (BZKG), Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany; Institut für Bio-Makromoleküle (bio-mac), Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany; Bayreuther Zentrum für Molekulare Biowissenschaften (BZMB), Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany; Bayreuther Materialzentrum (BayMAT), Universität Bayreuth, Universitätsstraße 30, Bayreuth 95440, Germany.
出版信息
Curr Opin Biotechnol. 2014 Oct;29:62-9. doi: 10.1016/j.copbio.2014.02.015. Epub 2014 Mar 20.
Spider silk has extraordinary mechanical properties, is biocompatible and biodegradable, and therefore an ideal material for biomedical applications. However, a drawback for any application is the inhomogeneity of spider silk, as seen for other natural materials, as well as the low availability due to the cannibalism of most spiders. Recently, developed recombinant spider silk proteins ensure constant material properties, as well as scalable production, and further the processing into morphologies other than fibres. Biotechnology enables genetic modification, broadening the range of applications, such as implant coatings, scaffolds for tissue engineering, wound dressing devices as well as drug delivery systems.
蜘蛛丝具有非凡的力学性能，具有生物相容性和可生物降解性，因此是生物医学应用的理想材料。然而，与其他天然材料一样，蜘蛛丝的不均匀性是其在任何应用中的一个缺点，而且由于大多数蜘蛛会同类相食，其可用性较低。最近，开发出的重组蜘蛛丝蛋白可确保材料性能恒定以及可扩展生产，还能进一步加工成纤维以外的形态。生物技术能够实现基因改造，拓宽应用范围，如植入物涂层、组织工程支架、伤口敷料装置以及药物递送系统。
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