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用于治疗应用的生物工程蜘蛛丝和氧化铁纳米粒子的复合球体。

Composite spheres made of bioengineered spider silk and iron oxide nanoparticles for theranostics applications.

机构信息

Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland.

Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland.

出版信息

PLoS One. 2019 Jul 15;14(7):e0219790. doi: 10.1371/journal.pone.0219790. eCollection 2019.

DOI:10.1371/journal.pone.0219790
PMID:31306458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6629150/
Abstract

Bioengineered spider silk is a biomaterial that has exquisite mechanical properties, biocompatibility, and biodegradability. Iron oxide nanoparticles can be applied for the detection and analysis of biomolecules, target drug delivery, as MRI contrast agents and as therapeutic agents for hyperthermia-based cancer treatments. In this study, we investigated three bioengineered silks, MS1, MS2 and EMS2, and their potential to form a composite material with magnetic iron oxide nanoparticles (IONPs). The presence of IONPs did not impede the self-assembly properties of MS1, MS2, and EMS2 silks, and spheres formed. The EMS2 spheres had the highest content of IONPs, and the presence of magnetite IONPs in these carriers was confirmed by several methods such as SEM, EDXS, SQUID, MIP-OES and zeta potential measurement. The interaction of EMS2 and IONPs did not modify the superparamagnetic properties of the IONPs, but it influenced the secondary structure of the spheres. The composite particles exhibited a more than two-fold higher loading efficiency for doxorubicin than the plain EMS2 spheres. For both the EMS2 and EMS2/IONP spheres, the drug revealed a pH-dependent release profile with advantageous kinetics for carriers made of the composite material. The composite spheres can be potentially applied for a combined cancer treatment via hyperthermia and drug delivery.

摘要

生物工程蜘蛛丝是一种具有精致机械性能、生物相容性和可生物降解性的生物材料。氧化铁纳米粒子可用于生物分子的检测和分析、靶向药物输送、磁共振成像对比剂以及基于热疗的癌症治疗的治疗剂。在这项研究中，我们研究了三种生物工程丝，即 MS1、MS2 和 EMS2，以及它们与磁性氧化铁纳米粒子 (IONP) 形成复合材料的潜力。IONP 的存在并不妨碍 MS1、MS2 和 EMS2 丝的自组装特性，并且形成了球体。EMS2 球体具有最高含量的 IONP，并且通过 SEM、EDXS、SQUID、MIP-OES 和 ζ 电位测量等多种方法证实了这些载体中存在磁铁矿 IONP。EMS2 和 IONP 的相互作用并没有改变 IONP 的超顺磁性，但它影响了球体的二级结构。与纯 EMS2 球体相比，复合粒子对阿霉素的负载效率提高了两倍以上。对于 EMS2 和 EMS2/IONP 球体，药物都表现出 pH 依赖性释放特性，对于由复合材料制成的载体来说，这是有利的动力学特性。复合球体可潜在应用于通过热疗和药物输送进行联合癌症治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/1f1af678b3d1/pone.0219790.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/11283c96a33c/pone.0219790.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/414ddf1b170f/pone.0219790.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/039a69c4da50/pone.0219790.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/acb2b2fd73a9/pone.0219790.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/1d60eef90ca9/pone.0219790.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/2fd293d220ba/pone.0219790.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/7b3230ea93a2/pone.0219790.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/1f1af678b3d1/pone.0219790.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/11283c96a33c/pone.0219790.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/414ddf1b170f/pone.0219790.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/039a69c4da50/pone.0219790.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/acb2b2fd73a9/pone.0219790.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/1d60eef90ca9/pone.0219790.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/2fd293d220ba/pone.0219790.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/7b3230ea93a2/pone.0219790.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/449f/6629150/1f1af678b3d1/pone.0219790.g008.jpg

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本文引用的文献

[1]
Blending two bioengineered spider silks to develop cancer targeting spheres.

J Mater Chem B. 2017-4-28

[2]
Bioengineering the spider silk sequence to modify its affinity for drugs.

Int J Nanomedicine. 2018-7-20

[3]
Potential use of superparamagnetic iron oxide nanoparticles for in vitro and in vivo bioimaging of human myoblasts.

Sci Rep. 2018-2-27

[4]
Delivery of chemotherapeutics using spheres made of bioengineered spider silks derived from MaSp1 and MaSp2 proteins.

Nanomedicine (Lond). 2018-1-17

[5]
The method of purifying bioengineered spider silk determines the silk sphere properties.

Sci Rep. 2016-6-17

[6]
A composited PEG-silk hydrogel combining with polymeric particles delivering rhBMP-2 for bone regeneration.

Mater Sci Eng C Mater Biol Appl. 2016-8-1

[7]
Study of magnetic silk fibroin nanoparticles for massage-like transdermal drug delivery.

Int J Nanomedicine. 2015-7-21

[8]
Enhanced cellular uptake of engineered spider silk particles.

Biomater Sci. 2015-1-13

[9]
Silk as an innovative biomaterial for cancer therapy.

Rep Pract Oncol Radiother. 2014-12-18

[10]
Biomimetic magnetic silk scaffolds.

ACS Appl Mater Interfaces. 2015-3-25

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