Duxbury A J, Thakker N S, Wastell D G
Br Dent J. 1989 Feb 25;166(4):115-20. doi: 10.1038/sj.bdj.4806731.
A double-blind, five phase, cross-over clinical trial was used to compare a mucin-based artificial saliva (Saliva Orthana) with its non-mucin base and water. Thirty patients, acting as their own controls, took part. Saliva Orthana offered significantly greater relief from xerostomia compared with its base or water, and was significantly better at relieving soreness than water. In terms of overall preference, it was ranked significantly higher than either alternative.
一项双盲、五阶段、交叉临床试验被用于比较一种基于粘蛋白的人工唾液（Saliva Orthana）与其非粘蛋白基底及水。30名患者作为自身对照参与了试验。与基底或水相比，Saliva Orthana能显著更好地缓解口干症，并且在缓解疼痛方面比水显著更有效。在总体偏好方面，它的排名显著高于其他任何一种替代品。
