Cancer Chemother Pharmacol. 2014 May;73(5):885-93. doi: 10.1007/s00280-014-2410-3.
T he correlation of apoptotic and proliferation index with preoperative chemotherapy efficacy was investigated. Their prognostic value was also explored.
167 patients were enrolled, curative gastrectomy and D2 lymphadenectomy were performed, and a total of 12 cycles of perioperative mFOLFOX7 chemotherapy was recommended. Apoptosis index (AI) and Ki67 index (KI) in surgical specimens were detected.
Apoptosis index, KI and AI/KI were significantly different between patients received perioperative chemotherapy and surgery (CS group, n = 84) and those who received only surgery and postoperative chemotherapy (S group, n = 83). In the CS group, number of patients who received 2, 4, 6 cycles of preoperative chemotherapy were, respectively, 28, 53 and 3. AI, KI and AI/KI were closely related to pathological response. Cutoff value of AI and AI/KI for response separated CS group patients into two subgroups with significant different prognosis and picked up more potential responders than pathological evaluation, especially in pathological response evaluation grade 1a–b.
Apoptosis index, KI and AI/KI are significantly related to chemotherapy efficacy and prognosis of gastric cancer patients who received perioperative chemotherapy and radical gastrectomy. They could be used in combination with pathological response evaluation to distinguish more potential responders.
研究细胞凋亡和增殖指数与术前化疗疗效的相关性，并探讨其预后价值。
共纳入 167 例患者，行根治性胃切除术和 D2 淋巴结清扫术，并推荐进行 12 个周期的围手术期 mFOLFOX7 化疗。检测手术标本中的凋亡指数（AI）和 Ki67 指数（KI）。
接受围手术期化疗和手术（CS 组，n=84）与仅接受手术和术后化疗（S 组，n=83）的患者之间，凋亡指数、KI 和 AI/KI 存在显著差异。在 CS 组中，接受 2、4、6 个周期术前化疗的患者分别为 28、53 和 3 例。AI、KI 和 AI/KI 与病理反应密切相关。AI 和 AI/KI 的截断值将 CS 组患者分为两组，其预后具有显著差异，且比病理评估能发现更多的潜在应答者，特别是在病理反应评估 1a–b 级时。
细胞凋亡指数、KI 和 AI/KI 与接受围手术期化疗和根治性胃切除术的胃癌患者的化疗疗效和预后显著相关。它们可与病理反应评估联合使用，以区分更多的潜在应答者。
