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小白菊对血小板行为的抑制作用:一种涉及巯基的作用机制。

Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups.

作者信息

Heptinstall S, Groenewegen W A, Spangenberg P, Lösche W

机构信息

Department of Medicine, University Hospital, Queen's Medical Centre, Nottingham, U.K.

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(4):447-9.

PMID:2465950
Abstract

Extracts of feverfew inhibit platelet aggregation and the platelet release reaction. The active components are believed to be sesquiterpene lactones such as parthenolide. Evidence is presented that inhibition of platelet behaviour is via neutralization of sulphydryl groups either inside or outside the cell. The precise nature of the sulphydryl groups that are susceptible to feverfew and are involved in platelet aggregation and the release reaction have not yet been defined.

摘要

小白菊提取物可抑制血小板聚集及血小板释放反应。其活性成分被认为是倍半萜内酯,如小白菊内酯。有证据表明,对血小板行为的抑制作用是通过中和细胞内或细胞外的巯基来实现的。尚未明确对小白菊敏感且参与血小板聚集和释放反应的巯基的确切性质。

相似文献

1
Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups.小白菊对血小板行为的抑制作用:一种涉及巯基的作用机制。
Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(4):447-9.
2
Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups.小白菊提取物可能通过中和巯基来抑制血小板活性。
J Pharm Pharmacol. 1987 Jun;39(6):459-65. doi: 10.1111/j.2042-7158.1987.tb03420.x.
3
Effects of an extract of feverfew (Tanacetum parthenium) on arachidonic acid metabolism in human blood platelets.小白菊提取物对人血小板中花生四烯酸代谢的影响。
Biomed Biochim Acta. 1988;47(10-11):S241-3.
4
Evidence for a cyclic GMP-independent mechanism in the anti-platelet action of S-nitrosoglutathione.S-亚硝基谷胱甘肽抗血小板作用中不依赖环鸟苷酸机制的证据。
Br J Pharmacol. 1998 May;124(1):141-8. doi: 10.1038/sj.bjp.0701821.
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A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro.小白菊提取物及其成分小白菊内酯对人血小板体外活性影响的比较。
J Pharm Pharmacol. 1990 Aug;42(8):553-7. doi: 10.1111/j.2042-7158.1990.tb07057.x.
6
Feverfew extracts and the sesquiterpene lactone parthenolide inhibit intercellular adhesion molecule-1 expression in human synovial fibroblasts.小白菊提取物和倍半萜内酯小白菊内酯可抑制人滑膜成纤维细胞中细胞间黏附分子-1的表达。
Cell Immunol. 2001 May 1;209(2):89-96. doi: 10.1006/cimm.2001.1797.
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A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium).一种来自药用植物小白菊(Tanacetum parthenium)的血小板磷脂酶抑制剂。
Prostaglandins Leukot Med. 1982 Jun;8(6):653-60.
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Effect of ketotifen and disodium cromoglycate on human platelet aggregation.酮替芬和色甘酸钠对人血小板聚集的影响。
Allergol Immunopathol (Madr). 1989 Jan-Feb;17(1):33-4.
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Protein S-glutathionylation and platelet anti-aggregating activity of disulfiram.双硫仑的蛋白质S-谷胱甘肽化作用及血小板抗聚集活性
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Inhibitory effect of aqueous extracts of some herbs on human platelet aggregation in vitro.某些草药水提取物对人血小板体外聚集的抑制作用。
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