面肩肱型肌营养不良症中定量肌肉超声与定量磁共振成像的比较
Quantitative muscle ultrasound versus quantitative magnetic resonance imaging in facioscapulohumeral dystrophy.
作者信息
Janssen Barbara H, Pillen Sigrid, Voet Nicoline B M, Heerschap Arend, van Engelen Baziel G M, van Alfen Nens
机构信息
Department of Radiology 766, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
出版信息
Muscle Nerve. 2014 Dec;50(6):968-75. doi: 10.1002/mus.24247. Epub 2014 Oct 30.
INTRODUCTION
Ultrasound and magnetic resonance imaging (MRI) are non-invasive methods that can be performed repeatedly and without discomfort. In the assessment of neuromuscular disorders it is unknown if they provide complementary information. In this study we tested this for patients with facioscapulohumeral muscular dystrophy (FSHD).
METHODS
We performed quantitative muscle ultrasound (QMUS) and quantitative MRI (QMRI) of the legs in 5 men with FSHD.
RESULTS
The correlation between QMUS-determined z-scores and QMRI-determined muscle fraction and T1 signal intensity (SI) was very high. QMUS had a wider dynamic range than QMRI, whereas QMRI could detect inhomogeneous distribution of pathology over the length of the muscles.
CONCLUSIONS
Both QMUS and QMRI are well suited for imaging muscular dystrophy. The wider dynamic range of QMUS can be advantageous in the follow-up of advanced disease stages, whereas QMRI seems preferable in pathologies such as FSHD that affect deep muscle layers and show inhomogeneous abnormality distributions.
引言
超声和磁共振成像（MRI）是无创检查方法，可重复进行且不会给患者带来不适。在评估神经肌肉疾病时，尚不清楚它们是否能提供互补信息。在本研究中，我们针对面肩肱型肌营养不良症（FSHD）患者对此进行了测试。
方法
我们对5名FSHD男性患者的腿部进行了定量肌肉超声（QMUS）和定量MRI（QMRI）检查。
结果
QMUS测定的z值与QMRI测定的肌肉分数和T1信号强度（SI）之间的相关性非常高。QMUS的动态范围比QMRI更宽，而QMRI能够检测到肌肉长度上病理变化的不均匀分布。
结论
QMUS和QMRI都非常适合对肌营养不良症进行成像。QMUS更宽的动态范围在晚期疾病阶段的随访中可能具有优势，而对于影响深层肌肉层且显示不均匀异常分布的疾病，如FSHD，QMRI似乎更具优势。
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