Mehrban Nazia, Abelardo Edgardo, Wasmuth Alexandra, Hudson Kieran L, Mullen Leanne M, Thomson Andrew R, Birchall Martin A, Woolfson Derek N
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Adv Healthc Mater. 2014 Sep;3(9):1387-91. doi: 10.1002/adhm.201400065. Epub 2014 Mar 24.
α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.
α-螺旋肽水凝胶装饰有细胞结合肽基序(RGDS),已证明该基序可促进PC12细胞的粘附、增殖和分化。功能化后凝胶结构和完整性得以维持。这为二维和三维细胞培养的复杂功能支架的自下而上设计和工程化开辟了可能性。