McGuinness Kenneth, Nanda Vikas
Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane West, Piscataway, NJ 08854, USA.
Org Biomol Chem. 2017 Jul 19;15(28):5893-5898. doi: 10.1039/c7ob01073g.
Collagen mimetic peptides that alone formed two-dimensional nanoscale discs driven by hydrophobic interactions were shown in electron microscopy studies to also co-assemble with natural fibrous proteins to produce discs-on-a-string (DoS) nanostructures. In most cases, peptide discs also facilitated bundling of the protein fibers. This provides insight into how synthetic and natural proteins may be combined to develop multicomponent, multi-dimensional architectures at the nanoscale.
在电子显微镜研究中显示，仅通过疏水相互作用就能形成二维纳米级圆盘的胶原模拟肽，也能与天然纤维蛋白共同组装，产生串上圆盘（DoS）纳米结构。在大多数情况下，肽圆盘还促进了蛋白质纤维的成束。这为如何将合成蛋白和天然蛋白结合起来以开发纳米级的多组分、多维结构提供了见解。
