Cohen Loren, Zabel Sonja, Rosychuk Rod A W
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.
J Am Anim Hosp Assoc. 2014 May-Jun;50(3):174-80. doi: 10.5326/JAAHA-MS-6028. Epub 2014 Mar 21.
Cyclosporine A (CsA) is a commonly prescribed and effective therapy for canine atopic dermatitis. The purpose of this study was to investigate the potential relationship between patient body weight and CsA dosing. Seventy-seven cases of canine atopic dermatitis managed between 2000 and 2011 were evaluated retrospectively. Duration of CsA therapy was at least 16 wk. Groups analyzed included the study population as a whole, those treated with only CsA, and those treated with both CsA and metoclopramide. The division between small and large dogs was set at 15 kg. Descriptive analysis, two-way analysis of variance, Pearson correlations, and a Student t test were used to analyze data. There were no significant differences between CsA dose and body weight regardless of method of analysis. Concurrent corticosteroid use, other medication use, and pruritus score were also analyzed over the study period. There was a significant decrease in CsA dose, corticosteroid dose, medication score, and pruritus score between the time points for all patients, but no significant relationship between those changes and body weight. These study findings suggest that differential CsA dosing is not warranted based on body weight.
环孢素A（CsA）是治疗犬特应性皮炎常用且有效的药物。本研究旨在调查病犬体重与CsA给药剂量之间的潜在关系。回顾性评估了2000年至2011年间收治的77例犬特应性皮炎病例。CsA治疗持续时间至少为16周。分析的组别包括整个研究群体、仅接受CsA治疗的犬只以及同时接受CsA和甲氧氯普胺治疗的犬只。小型犬与大型犬的划分标准设定为15千克。采用描述性分析、双向方差分析、Pearson相关性分析和Student t检验对数据进行分析。无论采用何种分析方法，CsA剂量与体重之间均无显著差异。在整个研究期间，还对同时使用皮质类固醇、使用其他药物情况以及瘙痒评分进行了分析。所有病犬在不同时间点的CsA剂量、皮质类固醇剂量、用药评分和瘙痒评分均显著降低，但这些变化与体重之间无显著关系。这些研究结果表明，无需根据体重调整CsA给药剂量。
