Ziemer S, Roeseler E, Monike A, Gromnica-Ihle E
Institute of Pathological and Clinical Biochemistry, Hospital of Humboldt, University Berlin, GDR.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(4):563-8.
The influence of therapeutic plasmapheresis by using membrane filter was investigated in 38 patients with 108 procedures. Fibrinogen and AT III reached most pronounced reduced levels in the course of three plasma exchanges while factors II, V, X, Hepato-Quick, Reptilase time and thrombocyte count remained relatively unchanged. There was no bleeding or thrombotic event in the patients. We concluded that at least determination of fibrinogen and AT III levels must be done just prior to each individual plasmapheresis to prevent dangerous imbalances in haemostatic system.
对38例患者进行了108次膜滤器治疗性血浆置换，研究其影响。在三次血浆置换过程中，纤维蛋白原和抗凝血酶III降至最显著的降低水平，而因子II、V、X、肝促凝血酶原激酶、蛇静脉酶时间和血小板计数相对保持不变。患者未发生出血或血栓形成事件。我们得出结论，为防止止血系统出现危险的失衡，至少在每次个体血浆置换前必须测定纤维蛋白原和抗凝血酶III水平。
