Sharma Suvasini, Jain Puneet, Gulati Sheffali, Sankhyan Naveen, Agarwala Anuja
Division of Pediatric Neurology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India Division of Pediatric Neurology, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India.
Division of Pediatric Neurology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
J Child Neurol. 2015 Apr;30(5):576-9. doi: 10.1177/0883073814527162. Epub 2014 Mar 20.
There is scanty data regarding the efficacy and tolerability of the modified Atkins diet in children with Lennox-Gastaut syndrome. This study was a retrospective review of children with Lennox-Gastaut syndrome treated with the modified Atkins diet from May 2009 and March 2011. The diet was initiated in those children who persisted to have daily seizures despite the use of at least 3 appropriate antiepileptic drugs. Twenty-five children were started on a modified Atkins diet, restricting carbohydrate intake to 10 g/d. After 3 months, 2 patients were seizure-free, and 10/25 children had >50% reduction in seizure frequency. At 6 months, of 11 patients on the diet, 3 were seizure free and 8 had >50% reduction in seizure frequency. At 1 year, all 9 children on diet had >50% reduction in seizure frequency. The side effects of the diet were mild. The modified Atkins diet was found to be effective and well tolerated in children with Lennox-Gastaut syndrome.
关于改良阿特金斯饮食法对伦诺克斯 - 加斯东综合征患儿的疗效和耐受性的数据较少。本研究是对2009年5月至2011年3月期间接受改良阿特金斯饮食法治疗的伦诺克斯 - 加斯东综合征患儿的回顾性研究。该饮食法应用于那些尽管使用了至少3种合适的抗癫痫药物仍每日发作癫痫的患儿。25名儿童开始采用改良阿特金斯饮食法，将碳水化合物摄入量限制在10克/天。3个月后，2名患儿无癫痫发作，25名儿童中有10名癫痫发作频率降低了50%以上。6个月时，在接受该饮食法的11名患儿中，3名无癫痫发作，8名癫痫发作频率降低了50%以上。1年时，所有9名接受该饮食法的儿童癫痫发作频率均降低了50%以上。该饮食法的副作用较轻。研究发现改良阿特金斯饮食法对伦诺克斯 - 加斯东综合征患儿有效且耐受性良好。
