Veroux Massimiliano, Corona Daniela, Sinagra Nunziata, Giaquinta Alessia, Zerbo Domenico, Ekser Burcin, Giuffrida Giuseppe, Caglià Pietro, Gula Riccardo, Ardita Vincenzo, Veroux Pierfrancesco
Massimiliano Veroux, Daniela Corona, Nunziata Sinagra, Alessia Giaquinta, Domenico Zerbo, Burcin Ekser, Giuseppe Giuffrida, Pietro Caglià, Riccardo Gula, Vincenzo Ardita, Pierfrancesco Veroux, Vascular Surgery and Organ Transplant Unit, Department of Surgery, Transplantation and Advanced Technologies, University Hospital of Catania, 95123 Catania, Italy.
World J Gastroenterol. 2014 Mar 21;20(11):2801-9. doi: 10.3748/wjg.v20.i11.2801.
The increasing demand for organ donors to supply the increasing number of patients on kidney waiting lists has led to most transplant centers developing protocols that allow safe utilization from donors with special clinical situations which previously were regarded as contraindications. Deceased donors with previous hepatitis C infection may represent a safe resource to expand the donor pool. When allocated to serology-matched recipients, kidney transplantation from donors with hepatitis C may result in an excellent short-term outcome and a significant reduction of time on the waiting list. Special care must be dedicated to the pre-transplant evaluation of potential candidates, particularly with regard to liver functionality and evidence of liver histological damage, such as cirrhosis, that could be a contraindication to transplantation. Pre-transplant antiviral therapy could be useful to reduce the viral load and to improve the long-term results, which may be affected by the progression of liver disease in the recipients. An accurate selection of both donor and recipient is mandatory to achieve a satisfactory long-term outcome.
对器官捐献者的需求不断增加，以满足越来越多等待肾移植患者的需求，这导致大多数移植中心制定了相关方案，允许安全利用以前被视为禁忌的具有特殊临床情况的捐献者。曾感染丙型肝炎的已故捐献者可能是扩大供体库的安全资源。当分配给血清学匹配的受者时，来自丙型肝炎捐献者的肾移植可能会带来出色的短期结果，并显著缩短等待名单上的时间。必须特别关注潜在供体的移植前评估，尤其是肝功能以及肝组织学损伤（如肝硬化）的证据，这些可能是移植的禁忌证。移植前抗病毒治疗可能有助于降低病毒载量并改善长期结果，长期结果可能会受到受者肝脏疾病进展的影响。为了获得令人满意的长期结果，对供体和受者进行准确选择是必不可少的。
