Prabhu Vinay, Lee Ted, McClintock Tyler R, Lepor Herbert
Department of Urology, New York University School of Medicine, New York, NY.
Rev Urol. 2013;15(4):161-77.
Many clinically localized prostate cancers that are diagnosed today are low risk, and prevention of disease-specific mortality may only be realized decades after treatment. Radical prostatectomy (RP) may adversely impact health-related quality of life (HRQOL) by causing both transient or permanent urinary incontinence and erectile dysfunction. In contrast, RP may also improve HRQOL via relief of lower urinary tract symptoms in men suffering from these symptoms prior to surgery. Because the average man treated for prostate cancer has a life expectancy of approximately 14 years, it is imperative to consider the long-term impact of RP on both survival and HRQOL in treatment decision making. This comprehensive literature review examines short-, intermediate-, and long-term HRQOL following RP. In addition, the long-term results of RP are compared with other treatment modalities for treating clinically localized prostate cancer.
如今诊断出的许多临床局限性前列腺癌风险较低，疾病特异性死亡的预防可能要在治疗数十年后才能实现。根治性前列腺切除术（RP）可能会导致短暂或永久性尿失禁以及勃起功能障碍，从而对健康相关生活质量（HRQOL）产生不利影响。相比之下，RP也可能通过缓解术前患有这些症状的男性的下尿路症状来改善HRQOL。由于接受前列腺癌治疗的男性平均预期寿命约为14年，因此在治疗决策中考虑RP对生存和HRQOL的长期影响至关重要。这篇全面的文献综述探讨了RP后的短期、中期和长期HRQOL。此外，还将RP的长期结果与治疗临床局限性前列腺癌的其他治疗方式进行了比较。
