Waters L M, Christensen M A, Sato R M
Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, CA 94305.
J Burn Care Rehabil. 1989 Jan-Feb;10(1):11-6.
Hetastarch is a synthetic polysaccharide colloid that has been used clinically in the management of multiple trauma, hypovolemic shock, and postoperative cardiac patients. Our objective was to determine whether hetastarch is a safe alternative to blood products in burn shock resuscitation. Twenty-six patients received hetastarch during the colloid phase of resuscitation and were compared to matched historical controls who received either albumin or fresh frozen plasma. Clinical and laboratory parameters were measured on admission and for 4 days after the burn. There was no significant difference in hemodynamics, respiratory status, incidence of bleeding, or renal or liver function among the three colloid groups. The advantages of hetastarch include immediate availability, no dependence on human blood donor population, no risk of serum-transmitted diseases, and lower cost. It can be safely recommended for those patients who object to blood products for resuscitation, in those situations where human donors are few, and when cost is a consideration.
羟乙基淀粉是一种合成多糖胶体，已在临床上用于治疗多处创伤、低血容量性休克和术后心脏病患者。我们的目的是确定羟乙基淀粉在烧伤休克复苏中是否是血液制品的安全替代品。26名患者在复苏的胶体阶段接受了羟乙基淀粉治疗，并与接受白蛋白或新鲜冷冻血浆的匹配历史对照进行了比较。在烧伤入院时及烧伤后4天测量临床和实验室参数。三个胶体组在血流动力学、呼吸状态、出血发生率或肾功能和肝功能方面没有显著差异。羟乙基淀粉的优点包括可立即获得、不依赖人类献血人群、无血清传播疾病风险且成本较低。对于那些反对使用血液制品进行复苏的患者、人类献血者较少的情况以及考虑成本的情况，可安全推荐使用羟乙基淀粉。
