Department of Surgery, Denver Health Medical Center and the University of Colorado School of Medicine, Denver, CO.
Department of Surgery, Denver Health Medical Center and the University of Colorado School of Medicine, Denver, CO.
J Am Coll Surg. 2014 May;218(5):1012-7. doi: 10.1016/j.jamcollsurg.2014.01.042. Epub 2014 Feb 3.
The role of stenting for blunt cerebrovascular injuries (BCVI) continues to be debated, with a trend toward more endovascular stenting. With the recent intracranial stenting trial halted in favor of medical therapy, however, management of BCVI warrants reassessment. The study purpose was to determine if antithrombotic therapy, rather than stenting, was effective in post-injury patients with high-grade vascular dissections and pseudoaneurysms.
In 1996, we began screening for BCVI. After the 2005 report on the risks of carotid stenting for BCVI, a virtual moratorium was placed on stenting at our institution; our primary therapy for BCVI has been antithrombotics. Patients with grade II (luminal narrowing >25%) and grade III (pseudoaneurysms) injuries were included in the analysis.
Grade II or III BCVIs were diagnosed in 195 patients. Before 2005, 25% (21 of 86) of patients underwent stent placement, with 2 patients suffering stroke. Of patients treated with antithrombotics, 1 had a stroke. After 2005, only 2% (2 of 109) of patients with high-grade injuries had stents placed. After 2005, no patient treated with antithrombotics suffered a stroke and there was no rupture of a pseudoaneurysm.
Antithrombotic treatment for BCVI is effective for stroke prevention. Routine stenting entails increased costs and potential risk for stroke, and does not appear to provide additional benefit. Intravascular stents should be reserved for the rare patient with symptomatology or a markedly enlarging pseudoaneurysm.
对于钝性脑血管损伤(BCVI)的支架治疗作用仍存在争议,倾向于更多的血管内支架治疗。然而,随着最近颅内支架试验因支持药物治疗而停止,BCVI 的治疗需要重新评估。本研究的目的是确定抗血栓治疗是否比支架治疗更有效,特别是在血管夹层和假性动脉瘤高分级的损伤患者中。
1996 年,我们开始筛选 BCVI。2005 年关于 BCVI 颈动脉支架治疗风险的报告发布后,我们机构对支架治疗采取了虚拟暂停;我们对 BCVI 的主要治疗方法是抗血栓治疗。本研究纳入了 II 级(管腔狭窄>25%)和 III 级(假性动脉瘤)损伤的患者。
195 例患者诊断为 II 级或 III 级 BCVI。2005 年之前,25%(86 例中的 21 例)的患者接受了支架治疗,其中 2 例发生卒中。接受抗血栓治疗的患者中,有 1 例发生卒中。2005 年之后,仅 2%(109 例中的 2 例)的高分级损伤患者接受了支架治疗。2005 年之后,接受抗血栓治疗的患者无一例发生卒中,也没有假性动脉瘤破裂。
抗血栓治疗 BCVI 可有效预防卒中。常规支架治疗会增加成本和卒中风险,且似乎没有额外获益。血管内支架应保留给有症状或假性动脉瘤明显增大的罕见患者。