婴儿自闭症中的血清素代谢及其他生化参数。对22名自闭症儿童的对照研究。

Serotonin metabolism and other biochemical parameters in infantile autism. A controlled study of 22 autistic children.

作者信息

Launay J M, Ferrari P, Haimart M, Bursztejn C, Tabuteau F, Braconnier A, Pasques-Bondoux D, Luong C, Dreux C

机构信息

Service de Biochimie et Neuroendocrinologie, Hôpital Saint-Louis, Paris, France.

出版信息

Neuropsychobiology. 1988;20(1):1-11. doi: 10.1159/000118465.

DOI:10.1159/000118465

PMID:2466221

Abstract

The serotonin metabolism was extensively studied in 22 couples of autistic children and age- and sex-matched controls. Histamine, calcium, and uric acid were also measured in urine and whole blood or plasma. Autistics and controls did not differ in histamine, and only minor changes were noticed in calcium content. According to previous reports, serotonin levels were often, but not always, elevated in the blood of autistic children. Based on data including urinary serotonin and 5-hydroxyindoleacetic acid, platelet serotonin uptake and efflux, platelet monoamine oxidase and glutathione peroxidase activities, and uric acid and plasma tryptophan, the origin(s) of such hyperserotonemia in autism appear(s) to be of metabolic origin, i.e., a decreased catabolism and/or an increased biosynthesis of serotonin.

摘要

对22对自闭症儿童及其年龄和性别匹配的对照组进行了广泛的血清素代谢研究。还测量了尿液、全血或血浆中的组胺、钙和尿酸。自闭症患者和对照组在组胺水平上没有差异，钙含量仅出现轻微变化。根据之前的报道，自闭症儿童血液中的血清素水平常常升高，但并非总是如此。基于包括尿血清素和5-羟吲哚乙酸、血小板血清素摄取和流出、血小板单胺氧化酶和谷胱甘肽过氧化物酶活性以及尿酸和血浆色氨酸在内的数据，自闭症中这种高血清素血症的起源似乎是代谢性的，即血清素分解代谢减少和/或生物合成增加。