Bursztejn C, Ferrari P, Dreux C, Braconnier A, Lancrenon S
Hôpital R. Debré, Reims.
Encephale. 1988 Nov-Dec;14(6):413-9.
In this controlled study of 22 autistic children and 22 normal controls matched for age and sex, the frequency of hyperserotonemia in infantile autism was confirmed. Platelet serotonin was elevated in patients. Comparative to controls, serotonin was also high in urine of autistic patients, while, on the contrary there was no difference for the urinary excretion of 5-HIAA. No difference was observed either for serotonin uptake and efflux or for MAO activity, in isolated platelets. The elevation of plasma free tryptophan - significant only with the Kolmogorov Smirnov test - suggests that 5-HT biosynthesis might be enhanced. In the group of patient reported in this study, disorders of serotonin metabolism are associated with disturbances of platelet catecholamines, and also with elevated immunoglobulins and enhanced cellular immunity reactions.
在这项针对22名自闭症儿童和22名年龄及性别匹配的正常对照儿童的对照研究中，婴幼儿自闭症患者高血清素血症的发生率得到了证实。患者的血小板血清素水平升高。与对照组相比，自闭症患者尿液中的血清素水平也较高，而5-羟吲哚乙酸的尿排泄量则无差异。在分离的血小板中，血清素摄取和流出以及单胺氧化酶活性均未观察到差异。血浆游离色氨酸升高——仅通过柯尔莫哥洛夫-斯米尔诺夫检验具有显著性——提示5-羟色胺生物合成可能增强。在本研究报道的患者组中，血清素代谢紊乱与血小板儿茶酚胺紊乱相关，也与免疫球蛋白升高和细胞免疫反应增强有关。
