自闭症患者与正常人的全血血清素水平。

Whole blood serotonin in autistic and normal subjects.

作者信息

Anderson G M, Freedman D X, Cohen D J, Volkmar F R, Hoder E L, McPhedran P, Minderaa R B, Hansen C R, Young J G

机构信息

Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06525.

出版信息

J Child Psychol Psychiatry. 1987 Nov;28(6):885-900. doi: 10.1111/j.1469-7610.1987.tb00677.x.

DOI:10.1111/j.1469-7610.1987.tb00677.x

PMID:3436995

Abstract

Whole blood serotonin and tryptophan were measured in 87 normal subjects and in 40 autistic subjects. Whole blood serotonin concentrations (mean +/- SE) were significantly higher in drug-free (N = 21) autistics (205 +/- 16 ng/ml) than in normals (136 +/- 5.4 ng/ml). The Gaussian distribution of serotonin levels in the unmedicated autistic group suggests the elevation was not due to a subgroup of autistic subjects. Autistics medicated with anticonvulsants or neuroleptics had significantly lower serotonin levels than did drug-free autistic subjects. Whole blood tryptophan levels and platelet counts were similar in the autistic and normal groups. The possible causes of the hyperserotonemia of autism are discussed.

摘要

对87名正常受试者和40名自闭症受试者进行了全血血清素和色氨酸检测。未用药的自闭症患者（N = 21）的全血血清素浓度（平均值±标准误）显著高于正常受试者（分别为205±16 ng/ml和136±5.4 ng/ml）。未用药的自闭症组血清素水平呈高斯分布，这表明血清素升高并非由部分自闭症患者导致。服用抗惊厥药或抗精神病药的自闭症患者血清素水平显著低于未用药的自闭症患者。自闭症组和正常组的全血色氨酸水平及血小板计数相似。文中讨论了自闭症患者血清素过多血症的可能成因。