Østensen Monika
National Center for Pregnancy and Rheumatic disease, Department of Rheumatology, University Hospital of Trondheim, Trondheim, Norway.
Curr Opin Rheumatol. 2014 May;26(3):302-7. doi: 10.1097/BOR.0000000000000044.
The purpose of this study is to encourage discussion of reproduction issues in all patients of fertile age in order to prevent unplanned and ill-timed pregnancies in patients with rheumatoid arthritis (RA).
Counselling patients who desire children requires consideration of relevant reproductive health issues, including fertility, interaction of pregnancy and RA, and management during pregnancy and lactation. RA patients have no disease-related restrictions in regard to contraception, but need to be counselled on safe birth control particularly during treatment with potentially teratogenic drugs. In spite of mostly beneficial effects of pregnancy on RA, active disease and aggressive drug treatment can impair pregnancy outcomes. Options for drug therapy, though limited, may help to maintain low disease activity during pregnancy and lactation.
Careful preconception counselling and risk assessment is important in RA women, with a particular focus on preventing unplanned pregnancy by information on contraception. Antibody status and all medications need to be reviewed before pregnancy. Maintaining low disease activity before and during pregnancy is crucial for good outcomes. Preconceptional counselling shared with all health professionals engaged in the care of a patient helps to ensure healthy pregnancy outcomes for mother and child.
本研究旨在鼓励对所有育龄患者的生殖问题进行讨论,以防止类风湿关节炎(RA)患者意外怀孕和怀孕时机不当。
为有生育意愿的患者提供咨询时,需要考虑相关生殖健康问题,包括生育能力、妊娠与类风湿关节炎的相互作用以及妊娠和哺乳期的管理。类风湿关节炎患者在避孕方面没有与疾病相关的限制,但需要就安全避孕进行咨询,尤其是在使用可能致畸的药物治疗期间。尽管妊娠对类风湿关节炎大多有有益影响,但活动性疾病和积极的药物治疗可能会损害妊娠结局。药物治疗选择虽然有限,但可能有助于在妊娠和哺乳期维持低疾病活动度。
对类风湿关节炎女性进行仔细的孕前咨询和风险评估很重要,特别要通过提供避孕信息来预防意外怀孕。怀孕前需复查抗体状态和所有药物。在怀孕前和怀孕期间维持低疾病活动度对良好结局至关重要。与参与患者护理的所有医护人员共同进行孕前咨询有助于确保母婴获得健康的妊娠结局。