循环长非编码 RNA，LIPCAR，可预测心力衰竭患者的生存情况。

Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure.

机构信息

From the Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx (R.K., I.V., J.F., A.H., T.T.) and REBIRTH Excellence Cluster (T.T.), Hannover Medical School, Hannover, Germany; Inserm, U744, University Lille Nord de France, Lille, France (C.B., F.M., G.L., P.d.G., F.P.); Institut Pasteur de Lille, Lille, France (C.B., F.M., G.L., P.d.G., F.P.); Centre Hospitalier Régional et Universitaire de Lille, Lille, France (C.B., G.L., P.d.G., F.P.); Faculté de Médecine de Lille, Lille, France (C.B., G.L.); and National Heart and Lung Institute, Imperial College London, London, United Kingdom (T.T.).

出版信息

Circ Res. 2014 May 9;114(10):1569-75. doi: 10.1161/CIRCRESAHA.114.303915. Epub 2014 Mar 24.

DOI:10.1161/CIRCRESAHA.114.303915

PMID:24663402

Abstract

RATIONALE

Long noncoding RNAs represent a novel class of molecules regulating gene expression. Long noncoding RNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease.

OBJECTIVE

To study the role of long noncoding RNAs as potential biomarkers in heart disease.

METHODS AND RESULTS

Global transcriptomic analyses were done in plasma RNA from patients with or without left ventricular remodeling after myocardial infarction. Regulated candidates were validated in 3 independent patient cohorts developing cardiac remodeling and heart failure (788 patients). The mitochondrial long noncoding RNA uc022bqs.1 (LIPCAR) was downregulated early after myocardial infarction but upregulated during later stages. LIPCAR levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths.

CONCLUSIONS

LIPCAR is a novel biomarker of cardiac remodeling and predicts future death in patients with heart failure.

摘要

背景

长非编码 RNA 是一类新的调节基因表达的分子。长非编码 RNA 存在于体液中，但它们作为心血管疾病生物标志物的潜力从未被研究过。

目的

研究长非编码 RNA 作为心脏病潜在生物标志物的作用。

方法和结果

对心肌梗死后左心室重构患者或无左心室重构患者的血浆 RNA 进行了全转录组分析。在 3 个独立的发生心肌重构和心力衰竭的患者队列中对受调控的候选物进行了验证（788 例患者）。线粒体长非编码 RNA uc022bqs.1（LIPCAR）在心梗后早期下调，但在晚期上调。LIPCAR 水平可识别发生心肌重构的患者，并与其他与未来心血管死亡相关的风险标志物独立相关。