ELA W21特异性的血清学和遗传学研究。

Serological and genetic study of the ELA W21 specificity.

作者信息

Hirni H, Lazary S, Gerber H

机构信息

Klinik fur Nutztiere und Pferde, School of Veterinary Medicine, University of Berne, Switzerland.

出版信息

Anim Genet. 1988;19(4):391-4. doi: 10.1111/j.1365-2052.1988.tb00830.x.

DOI:10.1111/j.1365-2052.1988.tb00830.x

PMID:2466423

Abstract

Investigations on the W21 specificity showed that this antigen is expressed on lymphocytes and platelets but not on erythrocytes. The molecule carrying the antigen W21 moves in the cell membrane independently from ELA locus A and B encoded antigens, as observed in 'lysostripping'. The W21 specificity occurs with very different gene frequencies in various breeds. In informative families it segregates together with defined gene products of the MHC region. The data suggest strongly that the W21 specificity belongs to the ELA system as a class I gene product, but is governed by a separate locus than the known locus A and locus B allelic series.

摘要

对W21特异性的研究表明，这种抗原在淋巴细胞和血小板上表达，但在红细胞上不表达。携带抗原W21的分子在细胞膜中移动，独立于ELA基因座A和B编码的抗原，如在“溶酶体剥离”中观察到的那样。W21特异性在不同品种中以非常不同的基因频率出现。在信息丰富的家系中，它与MHC区域的特定基因产物一起分离。数据强烈表明，W21特异性作为I类基因产物属于ELA系统，但由一个与已知的基因座A和基因座B等位基因系列不同的单独基因座控制。