Lazary S, Dubath M L, Luder C, Gerber H
J Immunogenet. 1986 Aug;13(4):315-25. doi: 10.1111/j.1744-313x.1986.tb01116.x.
A case of recombination between the putative class I ELA antigen series and the structure(s) governing mixed lymphocyte reactivity in an informative horse family is described. The results of serological typing, 'lysostripping' and mixed lymphocyte culture tests strongly suggest that the recombination took place between two loci and is not intragenic. An alloantigenic membrane structure, provisionally called B1, which does not belong to the known ELA series, was also involved in the cross-over. The B1 antigen resembles the class II gene products of other species in two respects: it is not present on platelets, and alloantiserum with specificity for B1 inhibits the stimulatory effect of B1-carrying cells in mixed lymphocyte cultures. The B1 antigen does not follow the classical distribution, however, being expressed on both B and T lymphocytes. The finding of separate loci for the first series of ELA antigens and the MLR governing structure(s) demonstrates the similarity of the genetic organization of the horse MHC to that in other species.
本文描述了一个信息丰富的马家族中，假定的I类ELA抗原系列与控制混合淋巴细胞反应性的结构之间发生重组的案例。血清学分型、“溶菌酶剥离”和混合淋巴细胞培养试验的结果强烈表明，重组发生在两个基因座之间，而非基因内重组。一种暂称为B1的同种异体抗原膜结构也参与了此次交换，该结构不属于已知的ELA系列。B1抗原在两个方面类似于其他物种的II类基因产物：它不存在于血小板上，且对B1具有特异性的同种抗血清可抑制混合淋巴细胞培养中携带B1细胞的刺激作用。然而，B1抗原并不遵循经典分布，它在B淋巴细胞和T淋巴细胞上均有表达。首次发现ELA抗原系列和MLR控制结构的独立基因座，证明了马MHC的遗传组织与其他物种相似。
