Guler Ismail, Himmetoglu Ozdemir, Turp Ahmet, Erdem Ahmet, Erdem Mehmet, Onan M Anıl, Taskiran Cagatay, Taslipinar Mine Yavuz, Guner Haldun
Department of Obstetrics & Gynecology, Faculty of Medicine, Gazi University, 06500 Besevler, Ankara, Turkey,
Biol Trace Elem Res. 2014 Jun;158(3):297-304. doi: 10.1007/s12011-014-9941-7. Epub 2014 Mar 26.
In this study, our objective was to evaluating the value of serum zinc levels as an etiologic and prognostic marker in patients with polycystic ovarian syndrome. We conducted a prospective study, including 53 women with polycystic ovarian syndrome and 33 healthy controls. We compared serum zinc levels, as well as clinical and metabolic features, of the cases. We also compared serum zinc levels between patients with polycystic ovarian syndrome with insulin resistance. Mean zinc levels were found to be significantly lower in patients with polycystic ovarian syndrome than healthy controls. Multiple logistic regression analysis of significant metabolic variables between polycystic ovarian syndrome and control groups (serum zinc level, body mass index, the ratio of triglyceride/high-density lipoprotein cholesterol, and homocysteine) revealed that zinc level was the most significant variable to predict polycystic ovarian syndrome. Mean serum zinc levels tended to be lower in patients with polycystic ovarian syndrome with impaired glucose tolerance than patients with normal glucose tolerance, but the difference was not statistically significant. In conclusion, zinc deficiency may play a role in the pathogenesis of polycystic ovarian syndrome and may be related with its long-term metabolic complications.
在本研究中，我们的目的是评估血清锌水平作为多囊卵巢综合征患者病因及预后标志物的价值。我们进行了一项前瞻性研究，纳入了53例多囊卵巢综合征女性患者和33例健康对照者。我们比较了病例组的血清锌水平以及临床和代谢特征。我们还比较了伴有胰岛素抵抗的多囊卵巢综合征患者之间的血清锌水平。结果发现，多囊卵巢综合征患者的平均锌水平显著低于健康对照者。对多囊卵巢综合征组和对照组之间的显著代谢变量（血清锌水平、体重指数、甘油三酯/高密度脂蛋白胆固醇比值和同型半胱氨酸）进行多因素逻辑回归分析显示，锌水平是预测多囊卵巢综合征的最显著变量。糖耐量受损的多囊卵巢综合征患者的平均血清锌水平往往低于糖耐量正常的患者，但差异无统计学意义。总之，锌缺乏可能在多囊卵巢综合征的发病机制中起作用，并且可能与其长期代谢并发症有关。
