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多囊卵巢综合征女性中与氧化应激相关的重金属和必需元素——一项系统综述

Heavy Metals and Essential Elements in Association with Oxidative Stress in Women with Polycystic Ovary Syndrome-A Systematic Review.

作者信息

Srnovršnik Tinkara, Virant-Klun Irma, Pinter Bojana

机构信息

Division for Women's Healthcare-Šiška Unit, Community Health Centre Ljubljana, Metelkova Ulica 9, 1000 Ljubljana, Slovenia.

Faculty of Medicine, University of Ljubljana, Vrazov Trg 2, 1000 Ljubljana, Slovenia.

出版信息

Antioxidants (Basel). 2023 Jul 7;12(7):1398. doi: 10.3390/antiox12071398.

DOI:10.3390/antiox12071398
PMID:37507937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10376316/
Abstract

Altered levels of heavy metals and essential elements have been associated with oxidative stress (OS) and metabolic and hormonal changes in women with polycystic ovary syndrome (PCOS). We aimed to summarize the knowledge on the association of heavy metals and essential elements with OS in PCOS. An electronic literature search using PubMed for studies published between January 2008 and April 2023 was conducted. We evaluated heavy metals and essential elements in relation to OS in PCOS in 15 articles. PCOS women had increased antimonium (Sb), cadmium (Cd), lead (Pb), mercury (Hg), arsenic (As), tellurium (Te), thallium (Tl) and osmium (Os) blood levels and decreased zinc (Zn) blood levels; the results of copper (Cu) blood levels were conflicting. Some studies showed a significant correlation between heavy metals (Sb, Cd, Pb, Hg, As, Te and Tl) and essential elements (Se, Zn, Cr, Ca, Mg and Cu) and markers of OS and chronic inflammation. Heavy metals (Sb, Cd, Pb and Hg) and essential elements (Zn, Cr, Se, Ca, Mg and Cu) were associated with metabolic and hormonal characteristics in PCOS. There might be a possible benefit from supplementation therapy in reducing OS and endocrinological problems related to PCOS. Our review confirmed an association between heavy metals and essential elements with OS in PCOS women. This systematic review is registered in PROSPERO under number CRD42023418453.

摘要

多囊卵巢综合征（PCOS）女性体内重金属和必需元素水平的改变与氧化应激（OS）、代谢及激素变化有关。我们旨在总结关于PCOS中重金属和必需元素与OS之间关联的知识。利用PubMed对2008年1月至2023年4月发表的研究进行了电子文献检索。我们在15篇文章中评估了PCOS中与OS相关的重金属和必需元素。PCOS女性的血液中锑（Sb）、镉（Cd）、铅（Pb）、汞（Hg）、砷（As）、碲（Te）、铊（Tl）和锇（Os）水平升高，锌（Zn）水平降低；铜（Cu）的血液水平结果存在矛盾。一些研究表明重金属（Sb、Cd、Pb、Hg、As、Te和Tl）和必需元素（Se、Zn、Cr、Ca、Mg和Cu）与OS及慢性炎症标志物之间存在显著相关性。重金属（Sb、Cd、Pb和Hg）和必需元素（Zn、Cr、Se、Ca、Mg和Cu）与PCOS的代谢和激素特征相关。补充疗法在减轻与PCOS相关的OS和内分泌问题方面可能有益。我们的综述证实了PCOS女性中重金属和必需元素与OS之间的关联。本系统评价已在PROSPERO注册，注册号为CRD42023418453。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a6/10376316/712ed7f1d36a/antioxidants-12-01398-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a6/10376316/6ba870ff80d4/antioxidants-12-01398-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a6/10376316/901edb6e534d/antioxidants-12-01398-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a6/10376316/712ed7f1d36a/antioxidants-12-01398-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a6/10376316/6ba870ff80d4/antioxidants-12-01398-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a6/10376316/901edb6e534d/antioxidants-12-01398-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25a6/10376316/712ed7f1d36a/antioxidants-12-01398-g003.jpg

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