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芳胺、丙炔酸甲酯和异吲哚酮酸催化一锅反应的分子多样性

Molecular diversity of acid-catalyzed one-pot reaction of arylamines, methyl propiolate, and isatins.

作者信息

Gao Hong, Sun Jing, Yan Chao-Guo

机构信息

College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, 225002, China.

出版信息

Mol Divers. 2014 Aug;18(3):511-9. doi: 10.1007/s11030-014-9512-z. Epub 2014 Mar 25.

DOI:10.1007/s11030-014-9512-z
PMID:24664284
Abstract

Under the catalysis of p-TsOH, ß-enamino esters, generated in situ from the reaction of arylamines and propiolate, were reacted with isatins to afford isatinylidene bis(3-arylamino)acrylates in moderate yields. When BF3·OEt2 was used as catalyst, similar reactions of the in situ generated ß-enamino esters resulted in the corresponding spiro[indoline-3,4'-pyridine] derivatives in good yields.

摘要

在对甲苯磺酸的催化下，芳胺与丙炔酸酯反应原位生成的β-烯胺酯与异吲哚酮反应，以中等产率得到异吲哚酮亚基双（3-芳基氨基）丙烯酸酯。当使用三氟化硼乙醚作为催化剂时，原位生成的β-烯胺酯的类似反应以良好的产率得到相应的螺[吲哚啉-3,4'-吡啶]衍生物。

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本文引用的文献

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Facile synthesis of dispirooxindole-fused heterocycles via domino 1,4-dipolar addition and Diels-Alder reaction of in situ generated Huisgen 1,4-dipoles.通过原位生成的Huisgen 1,4-二偶极子的 1,4-偶极加成和 Diels-Alder 反应，简便合成了螺环氧化吲哚杂环。
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