Welsh L W, Welsh J J, Rizzo T A
Ann Otol Rhinol Laryngol. 1989 Mar;98(3):228-34. doi: 10.1177/000348948909800313.
This project investigated the potential spread of cancer within the larynx by an analysis of the permeability and resistance of the subepithelial spaces. Permeation and diffusion of dye injections in the loose connective tissues below the epithelium was analyzed by histologic preparations in the sagittal plane. The margins of the infusion were identified grossly and microscopically, and the influence of the fibrous, elastic, and muscular components was analyzed with reference to the dispersion of the dyes. A close correlation between laboratory data from normal postmortem larynges and clinical problems of laryngeal cancer was observed in this study.
本项目通过分析上皮下间隙的通透性和阻力，研究了癌症在喉内的潜在扩散情况。通过矢状面的组织学切片，分析了染料注入上皮下方疏松结缔组织后的渗透和扩散情况。大体和显微镜下确定了注入边缘，并参照染料的扩散情况分析了纤维、弹性和肌肉成分的影响。本研究观察到正常死后喉部的实验室数据与喉癌临床问题之间存在密切关联。
