Department of Cell and Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. La Jolla, 92014, San Diego, CA, USA,
Adv Exp Med Biol. 2014;801:275-81. doi: 10.1007/978-1-4614-3209-8_35.
Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.
二十多年来，血管内皮生长因子 (VEGF) 在包括年龄相关性黄斑变性 (AMD) 和糖尿病视网膜病变 (DR) 在内的视网膜疾病发病机制中发挥重要作用这一点变得越来越清楚。基于这些观察结果，正在开发针对血管内皮生长因子的治疗方法，并已获准用于治疗新生血管性眼病。缺氧诱导因子 (HIF) 是转录因子，在缺氧条件下稳定并激活，并诱导包括 VEGF 在内的基因产物的表达，这些基因产物是细胞在缺氧下存活所必需的。在这里，我们讨论了来自我们实验室和其他实验室的最新发现，这些发现定义了 HIF-VEGF 轴在视网膜中的作用。
