DJ-1 对视网膜色素上皮细胞氧化应激的调节作用。
Oxidative stress regulation by DJ-1 in the retinal pigment epithelium.
机构信息
Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, The Cole Eye Institute, i31, 9500 Euclid Avenue, 44195, Cleveland, OH, USA,
出版信息
Adv Exp Med Biol. 2014;801:649-54. doi: 10.1007/978-1-4614-3209-8_81.
Abstract
DJ-1 is a protein expressed in many tissues including the brain where it has been extensively studied due to its association with Parkinson's Disease (PD). DJ-1 was reported to function as an antioxidant, redox-sensitive molecular chaperone, and transcription regulator, which protected cells from oxidative stress by modifying signaling pathways that regulate cell survival. Here we discuss our progress toward characterization of the DJ-1 function in the protection of RPE to oxidative stress.
摘要
DJ-1 是一种在许多组织中表达的蛋白质，包括大脑，由于其与帕金森病（PD）的关联，因此在大脑中进行了广泛的研究。DJ-1 被报道具有抗氧化剂、氧化还原敏感的分子伴侣和转录调节因子的功能，通过修饰调节细胞存活的信号通路来保护细胞免受氧化应激。在这里，我们讨论了我们在表征 DJ-1 在保护 RPE 免受氧化应激中的功能方面的进展。
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本文引用的文献
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DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders.DJ-1 与帕金森病和其他与年龄相关疾病的氧化应激预防。
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Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1.稳定的半胱氨酸亚磺酸的形成对于帕金森病蛋白DJ-1的线粒体功能至关重要。
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