多功能聚乙二醇化多壁碳纳米管用于增强血池和肿瘤磁共振成像。
Multifunctional PEGylated multiwalled carbon nanotubes for enhanced blood pool and tumor MR imaging.
机构信息
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai, 201620, China; College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China.
出版信息
Adv Healthc Mater. 2014 Oct;3(10):1568-77, 1525. doi: 10.1002/adhm.201300631. Epub 2014 Mar 24.
Long-circulating multifunctional Gd(III)-loaded multiwalled carbon nanotubes (MWCNTs) modified with polyethylene glycol are designed and synthesized. The formed MWCNTs are water-dispersible, stable, and have good cytocompatibility and antifouling property. With the low r 2 /r 1 relaxivity ratio and relatively long blood circulation time, the multifunctional MWCNTs are able to be used as a platform for enhanced blood pool and tumor MR imaging.
设计并合成了一种长循环多功能的聚乙二醇修饰的 Gd(III)负载的多壁碳纳米管（MWCNTs）。形成的 MWCNTs 具有水分散性、稳定性和良好的细胞相容性及抗污性。由于低 r 2 /r 1 弛豫率和相对较长的血液循环时间，多功能 MWCNTs 可用作增强血池和肿瘤磁共振成像的平台。
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