Department of Psychiatry, Showa University Northern Yokohama Hospital, Kanagawa 224-8503, Japan.
Department of Psychiatry, Showa University Northern Yokohama Hospital, Kanagawa 224-8503, Japan ; Tokyo Metropolitan Tobu Medical Center for Persons with Developmental/Multiple Disabilities, Tokyo 136-0075, Japan.
Dis Markers. 2014;2014:459013. doi: 10.1155/2014/459013. Epub 2014 Feb 9.
We review the utility of serum anticholinergic activity (SAA) as a peripheral marker of anticholinergic activity (AA) in the central nervous system (CAA). We hypothesize that the compensatory mechanisms of the cholinergic system do not contribute to SAA if their system is intact and that if central cholinergic system deteriorates alone in conditions such as Alzheimer's disease or Lewy body dementia, CAA and SAA are caused by way of hyperactivity of inflammatory system and SAA is a marker of the anticholinergic burden in CNS. Taking into account the diurnal variations in the plasma levels of corticosteroids, which are thought to affect SAA, it should be measured at noon or just afterward.
我们回顾了血清抗胆碱能活性（SAA）作为中枢神经系统（CAA）抗胆碱能活性（AA）的外周标志物的效用。我们假设，如果胆碱能系统完整，其代偿机制不会导致 SAA 增加，而如果在阿尔茨海默病或路易体痴呆等情况下中枢胆碱能系统单独恶化，CAA 和 SAA 则是由炎症系统的过度活跃引起的，SAA 是中枢神经系统抗胆碱能负担的标志物。考虑到皮质类固醇的血浆水平存在昼夜变化，这被认为会影响 SAA，因此应该在中午或之后不久进行测量。
