Martinez-Arizala A, Long J B, Holaday J W
Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
Brain Res. 1988 Nov 15;473(2):385-8. doi: 10.1016/0006-8993(88)90871-2.
Thyrotropin releasing hormone (TRH), which has been shown to improve neurologic recovery following cervical contusive spinal injury in cats, has also recently been reported to prevent the neuronal damage produced by the intrathecal (i.t.) administration of the substance P antagonist, spantide. Spantide and other substance P antagonists share with dynorphin A (DYN A)-related peptides the ability to produce an acute hindlimb paralysis after i.t. administration in the rat. By virtue of this effect, DYN A has been implicated in the secondary injury mechanisms that follow spinal trauma. Since TRH was shown to reduce the degree of histopathological injury caused by i.t. spantide, we investigated the ability of TRH to prevent or ameliorate the acute hindlimb paralysis produced by the i.t. injection of the substance P antagonists, (D-Arg1,D-Trp7,9,Leu11)-substance P (spantide) and (D-Arg1,D-Pro2,D-Trp7,9,Leu11)-substance P, and DYN A in rats. In this study, TRH failed to improve motor function or survival following i.t. injections of substance P antagonists or DYN A.
促甲状腺激素释放激素（TRH）已被证明可改善猫颈椎挫伤性脊髓损伤后的神经功能恢复，最近也有报道称其可预防鞘内注射P物质拮抗剂spantide所产生的神经元损伤。Spantide和其他P物质拮抗剂与强啡肽A（DYN A）相关肽一样，在大鼠鞘内注射后具有产生急性后肢麻痹的能力。由于这种作用，DYN A被认为与脊髓创伤后的继发性损伤机制有关。鉴于TRH可减轻鞘内注射spantide所引起的组织病理学损伤程度，我们研究了TRH预防或改善鞘内注射P物质拮抗剂（D-Arg1，D-Trp7,9，Leu11）-P物质（spantide）和（D-Arg1，D-Pro2，D-Trp7,9，Leu11）-P物质以及DYN A在大鼠中所产生的急性后肢麻痹的能力。在本研究中，鞘内注射P物质拮抗剂或DYN A后，TRH未能改善运动功能或提高生存率。
