促甲状腺激素释放激素（TRH）可对抗P物质拮抗剂诱导的神经元损伤。
Thyrotropin-releasing hormone (TRH) counteracts neuronal damage induced by a substance P antagonist.
作者信息
Freedman J, Hökfelt T, Jonsson G, Post C
出版信息
Exp Brain Res. 1986;62(1):175-8. doi: 10.1007/BF00237413.
PMID:2420632
Abstract
Intrathecal administration of the substance P antagonist Spantide caused marked necrotic changes of the gray matter of the spinal cord extending several segments from the injection site. Intravenous treatment with several doses of thyrotropin releasing hormone before and after Spantide injection completely prevented the necrotic lesion.
摘要
鞘内注射P物质拮抗剂Spantide可导致脊髓灰质出现明显的坏死性改变，坏死范围从注射部位延伸至数个节段。在注射Spantide之前和之后静脉注射几剂促甲状腺激素释放激素，可完全预防坏死性病变。
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