Kolosov Dennis, Bui Phuong, Chasiotis Helen, Kelly Scott P
Department of Biology; York University; Toronto, ON, Canada.
Tissue Barriers. 2013 Jul 1;1(3):e25391. doi: 10.4161/tisb.25391. Epub 2013 Jun 19.
Teleost fishes are a large and diverse animal group that represent close to 50% of all described vertebrate species. This review consolidates what is known about the claudin (Cldn) family of tight junction (TJ) proteins in teleosts. Cldns are transmembrane proteins of the vertebrate epithelial/endothelial TJ complex that largely determine TJ permeability. Cldns achieve this by expressing barrier or pore forming properties and by exhibiting distinct tissue distribution patterns. So far, ~63 genes encoding for Cldn TJ proteins have been reported in 16 teleost species. Collectively, cldns (or Cldns) are found in a broad array of teleost fish tissues, but select genes exhibit restricted expression patterns. Evidence to date strongly supports the view that Cldns play a vital role in the embryonic development of teleost fishes and in the physiology of tissues and organ systems studied thus far.
硬骨鱼是一个庞大且多样的动物群体，占所有已描述脊椎动物物种的近50%。本综述整合了目前关于硬骨鱼紧密连接（TJ）蛋白的claudin（Cldn）家族的已知信息。Cldn是脊椎动物上皮/内皮TJ复合体的跨膜蛋白，在很大程度上决定了TJ的通透性。Cldn通过表现出屏障或成孔特性以及呈现不同的组织分布模式来实现这一点。到目前为止，在16种硬骨鱼物种中已报道了约63个编码Cldn TJ蛋白的基因。总体而言，Cldn（或Cldns）存在于多种硬骨鱼组织中，但某些基因表现出受限的表达模式。迄今为止的证据有力地支持了这样一种观点，即Cldn在硬骨鱼的胚胎发育以及迄今为止所研究的组织和器官系统的生理学中起着至关重要的作用。
