Turksen Kursad
Regenerative Medicine Program; Sprott Centre for Stem Cell Research; Ottawa Hospital Research Institute; Ottawa, ON Canada.
Tissue Barriers. 2013 Jul 1;1(3):e26750. doi: 10.4161/tisb.26750. Epub 2013 Oct 8.
Since the discovery of Claudins more than a decade ago, much has been learned about their structure-function relationships. Claudins are tetraspan membrane proteins responsible for the formation of tight junctions. In this capacity, Claudins form a tissue-specific selective permeability barrier that is critical for the function of the tissue. Claudins are developmentally regulated and expressed in a tissue- and cell-specific manner; chronic changes in their expression are associated with various disease states. The studies that have been put together in this Special Issue provide updates on both current knowledge as well as some of the unanswered questions and challenges in the field.
自十多年前发现闭合蛋白以来，人们对其结构与功能的关系已有诸多了解。闭合蛋白是负责紧密连接形成的四跨膜蛋白。在此功能中，闭合蛋白形成组织特异性的选择性渗透屏障，这对组织功能至关重要。闭合蛋白在发育过程中受到调控，并以组织和细胞特异性的方式表达；其表达的长期变化与多种疾病状态相关。本期特刊汇总的研究提供了该领域当前知识的更新，以及一些尚未解答的问题和挑战。
