Shrivastava Sushruta, Kataki Amal Chandra, Barmon Debabrata, Deka Pankaj, Bhuyan Chidananda, Bhargav Saikia J
Department of Gynaecologic Oncology, Dr. B. Borooah Cancer Institute (RCC), Gopinath Nagar, Guwahati, Assam, India.
Department of Medical Oncology, Dr. B. Borooah Cancer Institute (RCC), Gopinath Nagar, Guwahati, Assam, India.
South Asian J Cancer. 2014 Jan;3(1):33-7. doi: 10.4103/2278-330X.126516.
To study the clinical presentations of gestational trophoblastic neoplasia and its response to chemotherapy.
This is a retrospective study of 28 women of gestational trophoblastic neoplasia evaluated over a period of 6 years from January 2004 to December 2009. Patients were evaluated on the basis of their age, number of deliveries, history of abortion or molar pregnancy, and the treatment received. All patients were scored on the basis of WHO scoring system. Patients with low risk (score </=6) received single agent chemotherapy with methotrexate or actinomycin D. Patients with high risk (score >/=7) received multiple agent chemotherapy with EMACO regimen. After completion of chemotherapy patients were followed for a minimum of 2 years. The response to treatment was evaluated during follow-up by clinical examination, beta hCG levels and imaging as and when required.
Out of 28 women only 27 could be evaluated, because 1 patient was lost to follow-up. Out of 27 patients, 18 patients (66.67%) achieved complete remission with the first-line chemotherapy and additional 25.92% (7/27) achieved complete remission with second line chemotherapy resulting in complete remission of 92.5% (25/27).
Gestational trophoblastic neoplasia is curable if patient is properly evaluated and scored. It shows good response to chemotherapy.
研究妊娠滋养细胞肿瘤的临床表现及其对化疗的反应。
这是一项回顾性研究，对2004年1月至2009年12月这6年间评估的28例妊娠滋养细胞肿瘤患者进行了研究。根据患者的年龄、分娩次数、流产或葡萄胎妊娠史以及所接受的治疗对患者进行评估。所有患者均根据世界卫生组织评分系统进行评分。低风险（评分≤6）的患者接受甲氨蝶呤或放线菌素D单药化疗。高风险（评分≥7）的患者接受EMACO方案的多药化疗。化疗完成后，对患者至少随访2年。在随访期间，根据需要通过临床检查、β-hCG水平和影像学检查评估治疗反应。
28例患者中，仅27例可进行评估，因为1例患者失访。在27例患者中，18例（66.67%）在一线化疗后实现完全缓解，另外25.92%（7/27）在二线化疗后实现完全缓解，完全缓解率达92.5%（25/27）。
如果对患者进行适当的评估和评分，妊娠滋养细胞肿瘤是可治愈的。它对化疗反应良好。
