Single-agent therapy for nonmetastatic and low-risk gestational trophoblastic disease.

OBJECTIVE

To assess the effectiveness of single-agent chemotherapy in the treatment of nonmetastatic and low-risk metastatic gestational trophoblastic tumors.

STUDY DESIGN

The medical literature was reviewed concerning single-agent chemotherapy in the treatment of nonmetastatic and low-risk metastatic gestational trophoblastic tumors.

RESULTS

Methotrexate and actinomycin-D have achieved excellent and comparable remission rates with acceptable levels of toxicity.

CONCLUSION

The optimal single-agent chemotherapy for nonmetastatic and low-risk metastatic gestational trophoblastic tumors has not yet been identified and can be best determined through a prospective, randomized trial.