出生队列中9岁前的颗粒物产前暴露与人体测量学
Prenatal exposure to particulates and anthropometry through 9 years of age in a birth cohort.
作者信息
Trees Ian R, Saha Abhisek, Putnick Diane L, Clayton Priscilla K, Mendola Pauline, Sundaram Rajeshwari, Yeung Edwina H
机构信息
Epidemiology Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Biostatistics and Bioinformatics Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Pediatr Obes. 2025 Mar;20(3):e13202. doi: 10.1111/ijpo.13202. Epub 2025 Jan 9.
BACKGROUND
Previous research observed links between prenatal air pollution and risk of childhood obesity but the timing of the exposure is understudied.
AIM
We examined prenatal particulate matter (PM, PM) exposure and child anthropometry.
MATERIALS & METHODS: Children's body mass index z-scores (zBMI) at 0-3 (N = 4370) and 7-9 (n = 1191) years were derived from reported anthropometry at paediatric visits. We ran linear mixed models for six windows, adjusting for maternal, child, and neighbourhood factors.
RESULTS
PM exposure across pregnancy and at multiple windows was associated with higher zBMI in both early and middle childhood. For instance, one interquartile range increase in PM exposure during the first 2 weeks of pregnancy was associated with higher zBMI at 0-3 (0.05, 95% CI: 0.01, 0.10) and 7-9 (0.14, 95% CI: 0.02, 0.23). PM exposure during the final 2 weeks of gestation was associated with higher zBMI at 7-9 years (B: 0.12, 95% CI: 0.04, 0.22).
CONCLUSION
Even at low levels of air pollution, prenatal PM exposure was associated with higher zBMI in childhood.
背景
先前的研究观察到产前空气污染与儿童肥胖风险之间的联系，但暴露的时间尚未得到充分研究。
目的
我们研究了产前颗粒物（PM，PM）暴露与儿童人体测量学指标之间的关系。
材料与方法
0至3岁（N = 4370）和7至9岁（n = 1191）儿童的体重指数z评分（zBMI）来自儿科就诊时报告的人体测量数据。我们针对六个时间段运行了线性混合模型，并对母亲、儿童和邻里因素进行了调整。
结果
整个孕期以及多个时间段的PM暴露与儿童早期和中期较高的zBMI相关。例如，孕期前2周PM暴露增加一个四分位数间距与0至3岁时较高的zBMI相关（0.05，95%置信区间：0.01，0.10），以及7至9岁时较高的zBMI相关（0.14，95%置信区间：0.02，0.23）。妊娠最后2周的PM暴露与7至9岁时较高的zBMI相关（B：0.12，95%置信区间：0.04，0.22）。
结论
即使在低空气污染水平下，产前PM暴露也与儿童期较高的zBMI相关。
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