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澳大利亚1型肺炎链球菌暴发的分子特征分析

Molecular characterization of an Australian serotype 1 Streptococcus pneumoniae outbreak.

作者信息

Staples M, Graham R M A, Jennison A V, Ariotti L, Hicks V, Cook H, Krause V, Giele C, Smith H V

机构信息

Public Health Microbiology, Communicable Disease, Forensic and Scientific Services, Department of Health, Queensland,Australia.

Centre for Disease Control, Department of Health, Northern Territory,Australia.

出版信息

Epidemiol Infect. 2015 Jan;143(2):325-33. doi: 10.1017/S0950268814000648. Epub 2014 Mar 25.

Abstract

Serotype 1 Streptococcus pneumoniae is a cause of invasive pneumococcal disease (IPD) worldwide and has been associated with IPD outbreaks, while carriage is rarely detected in healthy adults or children. This study details an Australian multi-state and territory outbreak of serotype 1 S. pneumoniae IPD between 2010 and 2012. Molecular characterization demonstrated the outbreak was largely due to the clonal expansion of sequence type 306, MLVA type 261 S. pneumoniae serotype 1.

摘要

1型肺炎链球菌是全球侵袭性肺炎球菌疾病(IPD)的一个病因,且与IPD暴发有关,而在健康成人或儿童中很少检测到其携带情况。本研究详细介绍了2010年至2012年澳大利亚多个州和地区发生的1型肺炎链球菌IPD暴发。分子特征分析表明,此次暴发主要是由于序列型306、多重可变数目串联重复序列分析(MLVA)型261的1型肺炎链球菌的克隆性扩增。

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