Smith-Vaughan H, Marsh R, Mackenzie G, Fisher J, Morris P S, Hare K, McCallum G, Binks M, Murphy D, Lum G, Cook H, Krause V, Jacups S, Leach A J
Menzies School of Health Research, Darwin, Australia.
Clin Vaccine Immunol. 2009 Feb;16(2):218-21. doi: 10.1128/CVI.00283-08. Epub 2008 Dec 17.
Seven-valent pneumococcal conjugate vaccination commenced in 2001 for Australian indigenous infants. Pneumococcal carriage surveillance detected substantial replacement with nonvaccine serotypes and a cluster of serotype 1 carriage. Our aim was to review Streptococcus pneumoniae serotype 1 carriage and invasive pneumococcal disease (IPD) data for this population and to analyze serotype 1 isolates. Carriage data were collected between 1992 and 2004 in the Darwin region, one of the five regions in the Northern Territory. Carriage data were also collected in 2003 and 2005 from four regions in the Northern Territory. Twenty-six cases of serotype 1 IPD were reported from 1994 to 2007 in the Northern Territory. Forty-four isolates were analyzed by BOX typing and 11 by multilocus sequence typing. In the Darwin region, 26 children were reported carrying serotype 1 (ST227) in 2002 but not during later surveillance. Scattered cases of serotype 1 carriage were noted in two other regions. Cocolonization of serotype 1 with other pneumococcal serotypes was common (34% serotype 1-positive swabs). In conclusion, pneumococcal carriage studies detected intermittent serotype 1 carriage and an ST227 cluster in children in indigenous communities in the Northern Territory of Australia. There was no apparent increase in serotype 1 IPD during this time. The rate of serotype 1 cocolonization with other pneumococcal serotypes suggests that carriage of this serotype may be underestimated.
2001年，七价肺炎球菌结合疫苗开始在澳大利亚原住民婴儿中接种。肺炎球菌携带情况监测发现，非疫苗血清型大量取代以及1型血清型携带聚集现象。我们的目的是回顾该人群中肺炎链球菌1型携带情况和侵袭性肺炎球菌病（IPD）数据，并分析1型血清型分离株。1992年至2004年在北领地五个地区之一的达尔文地区收集了携带情况数据。2003年和2005年还从北领地的四个地区收集了携带情况数据。1994年至2007年，北领地报告了26例1型IPD病例。对44株分离株进行了BOX分型分析，对11株进行了多位点序列分型分析。在达尔文地区，2002年报告有26名儿童携带1型血清型（ST227），但在后来的监测中未发现。在其他两个地区也发现了散在的1型血清型携带病例。1型血清型与其他肺炎球菌血清型的共定植很常见（血清型1阳性拭子占34%）。总之，肺炎球菌携带情况研究发现，澳大利亚北领地原住民社区儿童中存在间歇性1型血清型携带和一个ST227聚集群。在此期间，1型IPD没有明显增加。1型血清型与其他肺炎球菌血清型的共定植率表明，该血清型的携带情况可能被低估。
