Dirección General de Atención Primaria, Subdirección de Promoción de la Salud y Prevención, Consejería de Sanidad, Comunidad de Madrid, Spain.
Vaccine. 2011 Aug 5;29(34):5740-6. doi: 10.1016/j.vaccine.2011.05.099. Epub 2011 Jun 15.
To ascertain the factors linked to invasive pneumococcal disease (IPD) caused by the different serotypes in the period 2007-2009, following the conjugate vaccine's inclusion in the childhood vaccination schedule, a total of 2013 IPD cases were reviewed. The mean annual incidence in this period was 10.74 cases per 100,000 inhabitans and the lethality was 8.8%. Overall serotype distribution displayed certain peculiarities, such as the high frequency of serotype 5. Serotype 3, male gender, sepsis and presence of risk factors were significantly associated with lethality. Vaccinated children under 5 years of age had a higher risk of disease due to serotype 19A. Serotype 8 was associated with the presence of underlying risk factors.
为了确定 2007-2009 年期间与不同血清型相关的侵袭性肺炎球菌病（IPD）的因素，在结合疫苗纳入儿童免疫接种计划后，对总共 2013 例 IPD 病例进行了回顾。在此期间，平均年发病率为每 10 万人中有 10.74 例，死亡率为 8.8%。总体血清型分布显示出一定的特点，例如血清型 5 的高频率。血清型 3、男性、败血症和存在危险因素与死亡率显著相关。5 岁以下接种疫苗的儿童因血清型 19A 而患病的风险更高。血清型 8 与存在潜在危险因素有关。
