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[FHIT基因启动子甲基化与肺癌风险的关系：一项荟萃分析]

[The relationship between FHIT gene promoter methylation and lung cancer risk: a meta-analysis].

作者信息

Sun Yichang

机构信息

Department of Medical Oncology, the First Affiliated Hospital, Nanyang Medical College, Nanyang 473058, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2014 Mar;17(3):233-7. doi: 10.3779/j.issn.1009-3419.2014.03.09.

DOI:10.3779/j.issn.1009-3419.2014.03.09
PMID:24667261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6019368/
Abstract

BACKGROUND

Tumor-suppressor gene promoter DNA methylation in tumor cells is associated with its reduced expression. FHIT (fragile histindine triad) was one of the important tumor suppressor genes which was found hypermethylated in the promoter region in most of tumors. The aim of this study is to evaluate the relationship between FIHT gene promother methylation and lung cancer risk by meta-analysis.

METHODS

By searching Pubmed, CNKI and Wanfang, the open published articles related to FHIT gene promoter methylation and lung carcinoma risk were collected. The odds ratio (OR) and range of FHIT gene of cancer tissue of lung cancer patients compared with normal lung tissue, plasma and the bronchial lavage fluid were pooled by statistical software Stata 11.0.

RESULTS

Eleven studies were finally included in this meta-analysis. The median methylation rate were P(median)=40.0% (0-68.3%), P(median)=8.7% (0-35.0%), P(media)n=33.3% (17.1%-38.3%) and P(median)=35.9% (31.1%-50.8%) in cancer tissue, NLT, BALF and plasm respectively. The pooled results showed the methylation rate in tumor tissue was much higer than that of NLT OR=5.82 (95%CI: 3.74-9.06, P<0.05), but without statistical significance for BALF OR=1.55 (95%CI: 0.89-2.70, P>0.05) and plasma OR=1.41 (95%CI: 0.90-2.20, P>0.05).

CONCLUSIONS

Hypermethylation of FHIT gene promoter region was found more frequent in cancer tissue than that of NLT which may demonstrated association between lung cancer risk and FHIT gene promoter methylation.

摘要

背景

肿瘤细胞中抑癌基因启动子DNA甲基化与其表达降低相关。FHIT（脆性组氨酸三联体）是重要的抑癌基因之一，在大多数肿瘤中其启动子区域存在高甲基化。本研究旨在通过荟萃分析评估FHIT基因启动子甲基化与肺癌风险之间的关系。

方法

通过检索PubMed、CNKI和万方数据库，收集已发表的与FHIT基因启动子甲基化和肺癌风险相关的文章。使用统计软件Stata 11.0汇总肺癌患者癌组织与正常肺组织、血浆及支气管灌洗液中FHIT基因的比值比（OR）及范围。

结果

本荟萃分析最终纳入11项研究。癌组织、正常肺组织、支气管灌洗液和血浆中的甲基化率中位数分别为P(中位数)=40.0%（0 - 68.3%）、P(中位数)=8.7%（0 - 35.0%）、P(中位数)=33.3%（17.1% - 38.3%）和P(中位数)=35.9%（31.1% - 50.8%）。汇总结果显示，肿瘤组织中的甲基化率显著高于正常肺组织，OR = 5.82（95%CI：3.74 - 9.06，P < 0.05），但支气管灌洗液OR = 1.55（95%CI：0.89 - 2.70，P > 0.05）和血浆OR = 1.41（95%CI：0.90 - 2.20，P > 0.05）无统计学意义。

结论

与正常肺组织相比，癌组织中FHIT基因启动子区域高甲基化更为常见，这可能表明肺癌风险与FHIT基因启动子甲基化之间存在关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3f3/6019368/f029d4510b42/zgfazz-17-3-233-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3f3/6019368/c485f36e7bc1/zgfazz-17-3-233-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3f3/6019368/700efec0c7f3/zgfazz-17-3-233-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3f3/6019368/f029d4510b42/zgfazz-17-3-233-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3f3/6019368/c485f36e7bc1/zgfazz-17-3-233-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3f3/6019368/700efec0c7f3/zgfazz-17-3-233-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3f3/6019368/f029d4510b42/zgfazz-17-3-233-3.jpg

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Role of Notch signalling pathway in cancer and its association with DNA methylation.Notch信号通路在癌症中的作用及其与DNA甲基化的关联。
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