Angsubhakorn S, Bhamarapravati N, Pradermwong A, Im-Emgamol N, Sahaphong S
Department of Pathobiology, Faculty of Science, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Int J Cancer. 1989 Mar 15;43(3):531-4. doi: 10.1002/ijc.2910430332.
This study was carried out in order to investigate the minimal exposure to lindane (LD, 99.72% gamma isomer of 1,2,3,4,5,6 hexachlorocyclohexane), a chlorinated hydrocarbon insecticide, required to protect against liver tumor induced by aflatoxin B1 (AFB1). Materials fed to Buffalo strain rats were as follows: LD 100 ppm; AFB1 1 ppm, LD 100 ppm plus AFB1 1 ppm; and control basal diet. The experimental animals were clinically observed and then serially killed at 1, 3, 5, 10, 15 and 82 weeks. Concurrent administration of LD with AFB1 to rats for more than 3 weeks totally inhibited the incidence of AFB1-induced hepatocellular carcinomas by week 82. Only 1 of 20 rats (5%) fed the same regimen for 1 week developed liver tumors. Animals given 1 ppm AFB1 singly for 15 weeks had a high liver tumor incidence (31.5%). No animals developed liver tumors in LD-treated and control groups. LD may inhibit AFB1-induced liver tumors by stimulating hepatic metabolism and excretion of AFB1 so that less carcinogen is available to liver tissue.
本研究旨在调查林丹（LD，1,2,3,4,5,6 - 六氯环己烷的99.72%γ异构体）（一种氯代烃杀虫剂）预防黄曲霉毒素B1（AFB1）诱导的肝肿瘤所需的最低暴露量。给布法罗品系大鼠喂食的材料如下：LD 100 ppm；AFB1 1 ppm，LD 100 ppm加AFB1 1 ppm；以及对照基础日粮。对实验动物进行临床观察，然后在第1、3、5、10、15和82周分批处死。在第82周时，LD与AFB1同时给大鼠给药超过3周可完全抑制AFB1诱导的肝细胞癌的发生率。在接受相同方案1周的20只大鼠中，只有1只（5%）发生了肝肿瘤。单独给予1 ppm AFB1 15周的动物肝肿瘤发生率很高（31.5%）。在接受LD处理的组和对照组中没有动物发生肝肿瘤。LD可能通过刺激肝脏对AFB1的代谢和排泄来抑制AFB1诱导的肝肿瘤，从而使肝组织可获得的致癌物减少。
