含有（苯并咪唑-2-基）苯的双核锌（II）配合物，通过诱导线粒体碎片化克服肝癌细胞中的耐药性。
Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation.
作者信息
Xie Qiang, Liu Shenggui, Li Xiaoling, Wu Qiong, Luo Zuandi, Fu Xiaoyan, Cao Wenqiang, Lan Guoqiang, Li Dan, Zheng Wenjie, Chen Tianfeng
机构信息
Department of Chemistry, Jinan University, Guangzhou 510632, China.
出版信息
Dalton Trans. 2014 May 21;43(19):6973-6. doi: 10.1039/c4dt00198b. Epub 2014 Mar 26.
PMID:24668337
Abstract
Herein we demonstrated that dinuclear zinc complexes could overcome drug resistance in R-HepG2 drug resistance hepatocellular carcinoma cells through induction of mitochondria-mediated apoptosis or by triggering mitochondria fragmentation, depletion of the membrane potential and intracellular ATP levels.
摘要
在此，我们证明双核锌配合物可通过诱导线粒体介导的凋亡或触发线粒体碎片化、膜电位耗竭和细胞内ATP水平，克服R-HepG2耐药性肝癌细胞中的耐药性。
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