印度北部稳定期慢性阻塞性肺疾病患者体重指数与血氧饱和度的相关性
Correlation of BMI and oxygen saturation in stable COPD in Northern India.
作者信息
Gupta Shiv Sagar, Gothi Dipti, Narula Gurpreet, Sircar Joydeep
机构信息
Department of Pulmonary Medicine, Era's Lucknow Medical College, Lucknow, India.
Department of Pulmonary Medicine, ESI Hospital, New Delhi, India.
出版信息
Lung India. 2014 Jan;31(1):29-34. doi: 10.4103/0970-2113.125891.
BACKGROUND
Chronic obstructive pulmonary disease (COPD) is associated with clinically relevant extra pulmonary manifestations; one of them is weight loss. However, there are very few studies from North India available in relation to body mass index (BMI) and Oxygen saturation (SpO2) with COPD.
AIMS
To study the prevalence of undernutrition among stable COPD patients and correlation of COPD severity with SpO2 and BMI.
SETTINGS AND DESIGN
A prospective study was carried out at a tertiary care hospital.
SUBJECTS AND METHODS
COPD patients were diagnosed and staged as per global initiative for chronic obstructive lung disease (GOLD) guidelines. SpO2 was measured using pulse oxymeter and BMI categorization was done as per new classification for Asian Indians (2009). Statistical analysis was done using Statistical Package for Social Sciences Version 15.0.
RESULTS
Out of 147 COPD patients, 85 (57.8%) were undernourished. The prevalence of undernourished BMI was 25%, 50.8%, 61.7%, and 80% in stage I, II, III and IV respectively; statistically significant (P < 0.050). The mean SpO2 was 95.50 ± 1.41, 95.05 ± 2.42, 94.37 ± 2.28 and 93.05 ± 1.39 in stage I, II, III and IV respectively; statistically significant (F = 4.723; P = 0.004).
CONCLUSIONS
The overall prevalence of under nutrition among COPD patients was 57.8%. With increasing COPD stage the BMI and median SpO2 value decreased in progressive manner. Association of SpO2 and COPD stages could be explored further in order to suggest an additional marker of disease severity that would add a new dimension in the management of COPD.
背景
慢性阻塞性肺疾病（COPD）与临床上相关的肺外表现有关；其中之一是体重减轻。然而，在印度北部，关于COPD患者的体重指数（BMI）和血氧饱和度（SpO2）的研究非常少。
目的
研究稳定期COPD患者中营养不良的患病率以及COPD严重程度与SpO2和BMI的相关性。
设置与设计
在一家三级护理医院进行了一项前瞻性研究。
研究对象与方法
根据慢性阻塞性肺疾病全球倡议（GOLD）指南对COPD患者进行诊断和分期。使用脉搏血氧仪测量SpO2，并根据亚洲印度人的新分类（2009年）进行BMI分类。使用社会科学统计软件包第15.0版进行统计分析。
结果
在147例COPD患者中，85例（57.8%）营养不良。I、II、III和IV期营养不良BMI的患病率分别为25%、50.8%、61.7%和80%；差异有统计学意义（P < 0.050）。I、II、III和IV期的平均SpO2分别为95.50 ± 1.41、95.05 ± 2.42、94.37 ± 2.28和93.05 ± 1.39；差异有统计学意义（F = 4.723；P = 0.004）。
结论
COPD患者中营养不良的总体患病率为57.8%。随着COPD分期的增加，BMI和SpO2中位数呈逐渐下降趋势。为了提出一种疾病严重程度的附加标志物，从而为COPD的管理增加一个新维度，可进一步探索SpO2与COPD分期之间的关联。
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