人类白细胞抗原CD37的一级结构，大鼠MRC OX - 44抗原的物种同源物。
The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen.
作者信息
Classon B J, Williams A F, Willis A C, Seed B, Stamenkovic I
机构信息
Medical Research Council Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, United Kingdom.
出版信息
J Exp Med. 1989 Apr 1;169(4):1497-502. doi: 10.1084/jem.169.4.1497.
Abstract
Comparison of NH2-terminal protein sequence from the rat OX-44 antigen with the sequence of the human CD37 antigen deduced from a cDNA clone shows that these antigens are species homologues. The CD37 sequence is 244 amino acids in length and lacks a conventional leader sequence. The molecule is likely to have an NH2-terminal cytoplasmic domain followed by three transmembrane sequences that lie within the first 110 amino acids. The rest of the molecule is hydrophillic and contains three sites for N-linked glycosylation.
摘要
将大鼠OX-44抗原的氨基末端蛋白质序列与从cDNA克隆推导的人CD37抗原序列进行比较，结果表明这些抗原是种属同源物。CD37序列长度为244个氨基酸，缺乏传统的前导序列。该分子可能有一个氨基末端胞质结构域，随后是位于前110个氨基酸内的三个跨膜序列。分子的其余部分是亲水的，包含三个N-连接糖基化位点。
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