Shinohara Keisuke, Hata Toshimichi
Shinrigaku Kenkyu. 2014 Feb;84(6):618-24. doi: 10.4992/jjpsy.84.618.
We investigated the effect of a post-training chronic infusion of N-methyl-D-aspartate (NMDA) receptor blocker on retention of spatial reference memory in rats. In Experiment 1, we trained 4 groups of rats for 4 days (4 trials/ day) in the Morris water maze task. In a single probe trial after retention intervals of 1, 7, 14, and 28 days, the 1-day group showed more goal crossings than shown by the other 3 groups. In Experiment 2, a chronic infusion of the NMDA receptor antagonist D-2-amino-5-phosphonovaleric acid (D-AP5) or a control vehicle into the lateral ventricle was initiated 1 day after the training session, and continued for 6 days. In the subsequent probe trial (7 days after training), the rats that had received the D-AP5 infusion showed significantly more goal crossings than the controls. These findings suggest that an NMDA receptor blockade following acquisition facilitates retention of spatial reference memory.
我们研究了训练后长期输注N-甲基-D-天冬氨酸（NMDA）受体阻滞剂对大鼠空间参考记忆保持的影响。在实验1中，我们将4组大鼠在莫里斯水迷宫任务中训练4天（每天4次试验）。在1、7、14和28天的记忆间隔后的单次探测试验中，1天组的目标穿越次数比其他3组更多。在实验2中，训练 session 后1天开始向侧脑室长期输注NMDA受体拮抗剂D-2-氨基-5-磷酸戊酸（D-AP5）或对照载体，并持续6天。在随后的探测试验（训练后7天）中，接受D-AP5输注的大鼠的目标穿越次数明显多于对照组。这些发现表明，习得后进行NMDA受体阻断有助于空间参考记忆的保持。
