一例升结肠高分化腺癌伴类癌肿瘤。
A case of very well-differentiated adenocarcinoma with carcinoid tumor in the ascending colon.
作者信息
Yamauchi Hayato, Sakurai Shinji, Tsukagoshi Ritsuko, Suzuki Masaki, Tabe Yuichi, Fukasawa Takaharu, Kiriyama Shinsuke, Fukuchi Minoru, Naitoh Hiroshi, Kuwano Hiroyuki
机构信息
1 Department of Surgery, Social Insurance Gunma Chuo General Hospital, Gunma, Japan.
出版信息
Int Surg. 2014 Mar-Apr;99(2):132-6. doi: 10.9738/INTSURG-D-13-00041.1.
Malignant tumors with mixed glandular and neuroendocrine characteristics with at least 30% of each component are classified as mixed adenoneuroendocrine carcinoma (MANEC) by the World Health Organization 2010 classification. We report here a case of very well-differentiated adenocarcinoma accompanied by carcinoid tumor, categorized as MANEC. A 41-year-old Japanese man was clinically diagnosed with ascending colon cancer and underwent right hemicolectomy. Using an immunohistologic technique, the pathologic diagnosis was very well-differentiated adenocarcinoma accompanied by carcinoid tumor and marked eosinophil infiltration, which was categorized as MANEC. By immunohistochemical analysis, tumor cells of the carcinoid component exhibited very low proliferation activity. Our case was thought to be MANEC without high malignant potential. MANEC as per the World Health Organization 2010 classification seems to include tumors with diverse grades of malignancy, and it might need to have subclassifications according to the malignancy potential of the tumor cells.
根据世界卫生组织2010年分类，具有混合腺性和神经内分泌特征且每种成分至少占30%的恶性肿瘤被归类为混合性腺神经内分泌癌（MANEC）。我们在此报告一例伴有类癌肿瘤的高分化腺癌病例，归类为MANEC。一名41岁的日本男性临床诊断为升结肠癌并接受了右半结肠切除术。采用免疫组织学技术，病理诊断为伴有类癌肿瘤和明显嗜酸性粒细胞浸润的高分化腺癌，归类为MANEC。通过免疫组化分析，类癌成分的肿瘤细胞增殖活性极低。我们的病例被认为是无高恶性潜能的MANEC。按照世界卫生组织2010年分类，MANEC似乎包括不同恶性程度的肿瘤，可能需要根据肿瘤细胞的恶性潜能进行亚分类。
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