时间依赖性比较评价大鼠急性氰化物中毒的一些重要生物标志物：有助于诊断。
Time-dependent comparative evaluation of some important biomarkers of acute cyanide poisoning in rats: an aid in diagnosis.
机构信息
Pharmacology and Toxicology Division, Defence Research and Development Establishment , Gwalior, Madhya Pradesh , India .
出版信息
Biomarkers. 2014 May;19(3):241-51. doi: 10.3109/1354750X.2014.902996. Epub 2014 Mar 27.
OBJECTIVE
The study focuses on time-dependent comparative evaluation of various biomarkers of acute cyanide poisoning in rats.
METHODS
Blood gas (analyzer), lactate, pyruvate, cyanide, thiocyanate (spectrophotometer) and 2-amino-2-thiazoline-4-carboxylic acid (ATCA; gas chromatography-mass spectrometry) in plasma or urine, and various physiological parameters (polygraph) were measured.
RESULTS
Cyanide poisoning was characterized by elevated lactate, cyanide, thiocyanate and ATCA concentrations in plasma up to 15 min, 4, 16 and 24 h, respectively, while high urinary thiocyanate and ATCA levels were measured between 4 and 24 h.
CONCLUSION
ATCA concentration in plasma and urine was found to be more reliable indicator of cyanide poisoning.
目的
本研究专注于对大鼠急性氰化物中毒的各种生物标志物进行时程比较评估。
方法
检测血液气体（分析仪）、乳酸、丙酮酸、氰化物、硫氰酸盐（分光光度计）和 2-氨基-2-噻唑啉-4-羧酸（ATCA；气相色谱-质谱联用仪）在血浆或尿液中的浓度，以及各种生理参数（多导记录仪）。
结果
氰化物中毒的特征为血浆中乳酸、氰化物、硫氰酸盐和 ATCA 浓度分别在 15 分钟、4 小时、16 小时和 24 小时升高，而高浓度的尿硫氰酸盐和 ATCA 则在 4 小时至 24 小时之间测量到。
结论
发现血浆和尿液中的 ATCA 浓度是更可靠的氰化物中毒指标。
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